The US announced on Thursday that Taobao Marketplace, owned by Chinese e-commerce giant Alibaba Group, has been removed from its yearly list of the world's most "notorious markets," so-called because they are rampant with pirated and counterfeit goods.Source: http://feedproxy.google.com/~r/Techcrunch/~3/tsmczElvncw/
nascar daytona 2012 kasey kahne angelina jolie right leg saving face academy award winners best picture 2012 oscar winners
Generating traffic is one of the key procedures associated with internet marketing. One of, if not the most captivating web traffic technique available at the moment is Pay-Per-Click advertising or PPC for short.
Essentially, PPC is an in internet advertising model, where advertisers pay the website owner when the ad on their site is clicked.
Most businesses locate their pay-per-click advertisement campaigns on search engine pages, online directories and popular social network sites. You want it on sites that have millions of users every day, so that the PPC advertising campaign can reach its full potential.
Furthermore, the PPC advertisement is placed on pages that contain related content and keywords, because let?s be honest, having an advertisement a suit tailor is pointless when the keyword the user uses is web design. Being placed amongst closely related content allows a process called sponsored match to take place. Sponsored is when a business can efficiently target potential customers searching for their niche, these types of customer are more likely to purchase also.
PPC advertising can be set up very quickly and provides a great deal of information to measure campaign performance. You only pay for ?click-throughs? so it can be a highly cost-effective form of advertising when implemented correctly. In order for your PPC Campaign to be successful, it requires strategic thinking, cutting-edge analysis and persistent management throughout. By continually assessing and adopting your tactics you can ensure that your campaign is optimized; maximizing your return on investment.
The literature within your PPC advertisement must be accurate and effective as this is the most vital component of your PPC campaign. Clearly, the aim of the advert is to attract targeted leads, however you barely have 100 characters to do this in, therefore your ad needs to be compelling in order to attract buyers.
Listed below are a few key pointers that should help you when writing your PPC advert:
??? ?Keep your content simple.
??? ?Include only the best keywords.
??? ?If you only target a certain geographical area such as London, ensure that you specify this within your PPC advert.
??? ?If you have a time-related benefit, ensure that you mention it. This will form a sense of pressure on the viewer to buy.
All being well, PPC does pose a possible threat.
The primary determinant when it comes to the costing of your PPC advert? is based on the popularity of the key word that you are trying to use. Evidentially, the more the key word is sought after, the higher the cost of using it will be. If this is the case, it is basically impossible for a business to utilize the targeted keywords that would yield the best results for their business.
Source: http://www.ebay-success-secrets.com/the-ins-and-outs-of-pay-per-click-advertising/
kristin chenoweth Robert Blake BLK Water ESPYs daniel tosh kate upton Jason Kidd
The number of options out there for iPad stylii at this point is almost crazy. But Ten One Design has always made solid ones, and the Pogo Connect also adds pressure sensitivity via Bluetooth 4.0. It's a slightly different take than others in this space, and one that benefits immensely from extremely low power consumption.Source: http://feedproxy.google.com/~r/Techcrunch/~3/rXrmqKC6L44/
orange bowl tim howard goal ben gibbard nfl playoff schedule tim howard scores nick cannon kidney failure consumer financial protection bureau
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 12-Dec-2012
Share ] Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
SEATTLE Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study. The findings, by Christopher I. Li, M.D., Ph.D., a member of the Public Health Sciences Division at Fred Hutch, are published online in Breast Cancer Research and Treatment.
"We found that the interval between menarche and age at first live birth is inversely associated with the risk of triple-negative breast cancer," Li said. While relatively uncommon, triple-negative breast cancer is a particularly aggressive subtype of the disease that does not depend on hormones such as estrogen to grow and spread. This type of cancer, which accounts for only 10 percent to 20 percent of all breast cancers, does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or HER2/neu and therefore does not respond to hormone-blocking drugs such as Tamoxifen.
The study by Li and colleagues in the Public Health Sciences and Human Biology divisions at Fred Hutch is the first to look at how the interval between first menstrual period and age at first birth is related to the risk of this particular type of breast cancer. It is also the first study to look at the relationship between reproductive factors and breast cancer risk among premenopausal women, who have a higher risk of triple-negative and HER2-overexpressing breast cancer than postmenopausal women.
The study also confirmed several previous studies that have suggested that breast-feeding confers a protective effect against triple-negative disease. "Breast-feeding is emerging as a potentially strong protective factor against one of the most aggressive forms of breast cancer," Li said.
The mechanism by which breast-feeding and delaying childbirth reduces the risk of this form of breast cancer is unclear, Li said.
Previous research has shown, however, that the risk of the most common subtype of breast cancer, ER positive, is decreased among women who've had a full-term pregnancy and have breast-fed. The reason for this, researchers believe, is that the hormones of pregnancy induce certain changes in the cellular structure of the breast that seem to make the tissue less susceptible to this type of cancer.
The study has particular implications for African-American women, who experience disproportionately high rates of triple-negative disease. While the reason for this remains largely unknown, on a population level reproductive characteristics are known to vary by race, and compared to non-Hispanic white women, African-American women are more likely to start having children at a younger age and are less likely to breast-feed, Li said.
"Our observations that delayed childbearing and breast-feeding are protective against triple-negative breast cancer suggest that variations in reproductive histories by race may to some extent explain the higher rates of triple-negative disease in African-American women," Li said.
The study involved more than 1,960 Seattle-area women between the ages of 20 and 44, 1,021 with a history of breast cancer and 941 without. Reproductive histories among women without a history of breast cancer were compared to those of women with ER-positive (781), triple-negative (180) and HER2-overexpressing (60) breast cancer.
"This is an observational study and also one of the first to focus on premenopausal breast cancer and so our results require confirmation and thus should be interpreted with some caution," Li said.
###
The National Cancer Institute and the Department of Defense Breast Cancer Research Program funded the study.
Editor's note: To obtain a copy of the Breast Cancer Research and Treatment paper, "Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age," visit http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s10549-012-2365-1
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Private contributions are essential for enabling Fred Hutch scientists to explore novel research opportunities that lead to important medical breakthroughs. For more information visit www.fhcrc.org or follow Fred Hutch on Facebook, Twitter or YouTube.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 12-Dec-2012 Share ] Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
SEATTLE Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study. The findings, by Christopher I. Li, M.D., Ph.D., a member of the Public Health Sciences Division at Fred Hutch, are published online in Breast Cancer Research and Treatment.
"We found that the interval between menarche and age at first live birth is inversely associated with the risk of triple-negative breast cancer," Li said. While relatively uncommon, triple-negative breast cancer is a particularly aggressive subtype of the disease that does not depend on hormones such as estrogen to grow and spread. This type of cancer, which accounts for only 10 percent to 20 percent of all breast cancers, does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or HER2/neu and therefore does not respond to hormone-blocking drugs such as Tamoxifen.
The study by Li and colleagues in the Public Health Sciences and Human Biology divisions at Fred Hutch is the first to look at how the interval between first menstrual period and age at first birth is related to the risk of this particular type of breast cancer. It is also the first study to look at the relationship between reproductive factors and breast cancer risk among premenopausal women, who have a higher risk of triple-negative and HER2-overexpressing breast cancer than postmenopausal women.
The study also confirmed several previous studies that have suggested that breast-feeding confers a protective effect against triple-negative disease. "Breast-feeding is emerging as a potentially strong protective factor against one of the most aggressive forms of breast cancer," Li said.
The mechanism by which breast-feeding and delaying childbirth reduces the risk of this form of breast cancer is unclear, Li said.
Previous research has shown, however, that the risk of the most common subtype of breast cancer, ER positive, is decreased among women who've had a full-term pregnancy and have breast-fed. The reason for this, researchers believe, is that the hormones of pregnancy induce certain changes in the cellular structure of the breast that seem to make the tissue less susceptible to this type of cancer.
The study has particular implications for African-American women, who experience disproportionately high rates of triple-negative disease. While the reason for this remains largely unknown, on a population level reproductive characteristics are known to vary by race, and compared to non-Hispanic white women, African-American women are more likely to start having children at a younger age and are less likely to breast-feed, Li said.
"Our observations that delayed childbearing and breast-feeding are protective against triple-negative breast cancer suggest that variations in reproductive histories by race may to some extent explain the higher rates of triple-negative disease in African-American women," Li said.
The study involved more than 1,960 Seattle-area women between the ages of 20 and 44, 1,021 with a history of breast cancer and 941 without. Reproductive histories among women without a history of breast cancer were compared to those of women with ER-positive (781), triple-negative (180) and HER2-overexpressing (60) breast cancer.
"This is an observational study and also one of the first to focus on premenopausal breast cancer and so our results require confirmation and thus should be interpreted with some caution," Li said.
###
The National Cancer Institute and the Department of Defense Breast Cancer Research Program funded the study.
Editor's note: To obtain a copy of the Breast Cancer Research and Treatment paper, "Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age," visit http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s10549-012-2365-1
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Private contributions are essential for enabling Fred Hutch scientists to explore novel research opportunities that lead to important medical breakthroughs. For more information visit www.fhcrc.org or follow Fred Hutch on Facebook, Twitter or YouTube.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-12/fhcr-dcm121212.php
triple play virginia tech shooting james neal jackie robinson virginia tech emancipation proclamation april 16
Nintendo may not be giving up its gaming IPs to smartphones just yet, but the Japanese gaming giant is willing to work with them if it means crosspromoting games on standalone Nintendo consoles. Take, for example, today's release of the interactive Pokémon "Pokédex," available for $2 across various iOS devices -- Nintendo clearly isn't against taking fans' money in exchange for a valuable service: information on over 640 Pokémon on-the-go ... if you buy the three upgrade packs for $5.99 apiece (!!), that is.
Support for the app extends all the way back to the aged iPhone 3GS, and through to the newest iPad (as well as the iPad Mini), so you'll be able to explore the wild world of Tepig from a vast array of iOS hardware. Of course, much of this could be meaningless to you if you grabbed the free version previously available on Nintendo's 3DS, but then you put it off, didn't you? And now here we are.
Continue reading Nintendo on iOS? Pok?dex arrives on iOS in the US and Europe, costs $2
Filed under: Cellphones, Gaming, Handhelds, Tablets, Software, Mobile, Nintendo
Source: iTunes
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/wCJZpRGyfZ4/
livan hernandez soledad o brien mega ball lottery winner lottery numbers mega millions lottery jackpot
KIGALI (Reuters) - Rwanda's year-on-year urban inflation fell to 4.55 percent in November, thanks to a drop in prices of food and non-alcoholic beverages, the statistics office said on Monday.
Prices of fish, vegetables and health services fell during the month. The landlocked central African nation's economic growth rose to 9.4 percent in the fiscal year ended last June from 7.4 percent previously.
But economic growth prospects could wane if donors, who suspended some aid over Rwanda's alleged support for rebels in the neighbouring Democratic Republic of Congo, fail to reinstate the aid soon, Finance Minister John Rwangombwa said.
Rwangombwa told a conference in Kigali last week that Rwanda may have to cut its 2013 economic growth forecast if $240 million in aid remains frozen.
Source: http://news.yahoo.com/rwanda-urban-inflation-falls-4-55-pct-november-112203294--business.html
blake lively Espn Fantasy Football Grandparents Day 2012 army wives 60 minutes go daddy Tom Kenny
FILE -In this June 17, 2010 file photo, former South African President, Nelson Mandela leaves the chapel after attending the funeral of his great-granddaughter Zenani Mandela in Johannesburg, South Africa. South African President Jacob Zuma says that former President Nelson Mandela has been admitted to hospital in Pretoria to undergo tests. Zuma issued a statement Saturday, Dec. 8, 2012 saying that Mandela is "doing well and there is no cause for alarm." (AP Photo/Siphiwe Sibeko, Pool, File)
FILE -In this June 17, 2010 file photo, former South African President, Nelson Mandela leaves the chapel after attending the funeral of his great-granddaughter Zenani Mandela in Johannesburg, South Africa. South African President Jacob Zuma says that former President Nelson Mandela has been admitted to hospital in Pretoria to undergo tests. Zuma issued a statement Saturday, Dec. 8, 2012 saying that Mandela is "doing well and there is no cause for alarm." (AP Photo/Siphiwe Sibeko, Pool, File)
FILE - In this Wednesday, July 18, 2012 file photo, former South African President Nelson Mandela as he celebrates his birthday with family in Qunu, South Africa. South African President Jacob Zuma says that former President Nelson Mandela has been admitted to hospital in Pretoria to undergo tests. Zuma issued a statement Saturday, Dec. 8, 2012 saying that Mandela is "doing well and there is no cause for alarm." (AP Photo/Schalk van Zuydam, File)
JOHANNESBURG (AP) ? South Africa's former President Nelson Mandela was admitted to a military hospital Saturday for medical tests, though the nation's president told the public there was "no cause for alarm" over the 94-year-old icon's health.
The statement issued by President Jacob Zuma's spokesman said that Mandela was doing well and was receiving medical care "which is consistent for his age." The statement offered no other details.
Mandela, who spent 27 years in prison for fighting racist white rule, became South Africa's first black president in 1994 and served one five-year term. He later retired from public life to live in his village of Qunu, and last made a public appearance when his country hosted the 2010 World Cup soccer tournament.
"We wish Madiba all the best," Zuma said in the statement, using Mandela's clan name. "The medical team is assured of our support as they look after and ensure the comfort of our beloved founding president of a free and democratic South Africa."
While the government sought to reassure South Africans about Mandela's health, he remains viewed as a father figure to many in this nation of 50 million people. Each hospital trip raises the same worries about the increasingly frail former leader of the African National Congress ? that the man who helped bring the nation together is slowly fading away.
In February, Mandela spent a night in a hospital for a minor diagnostic surgery to determine the cause of an abdominal complaint. In January 2011, however, Mandela was admitted to a Johannesburg hospital for what officials initially described as tests but what turned out to be an acute respiratory infection. He was discharged days later.
Mandela contracted tuberculosis during his years in prison. He also had surgery for an enlarged prostate gland in 1985.
While Zuma's statement offered no further details about who would provide medical attention for Mandela, the nation's military has taken over caring for the aging leader since the 2011 respiratory infection. At 1 Military Hospital in Pretoria on Saturday night, the facility that previously cared for Mandela in February, everything appeared calm, without any additional security present.
Mac Maharaj, a presidential spokesman, declined to say whether Mandela had been flown by the military from Qunu to Pretoria. He also declined to say what the tests were for.
"It's quite normal at his age to be going through those tests," Maharaj told The Associated Press.
Mandela's hospitalization comes just days after the crash of a military aircraft flying on an unknown mission near Mandela's rural home in which all 11 onboard were killed.
The plane was flying to a military air base in Mthatha, which is about 30 kilometers (17 miles) north of Qunu. Military officials declined to say whether those on board had any part in caring for Mandela.
___
Associated Press writers Thomas Phakane in Pretoria, South Africa, and Andrew Meldrum in Johannesburg contributed to this report.
___
Jon Gambrell can be reached at www.twitter.com/jongambrellAP .
Associated PressChad Johnson London 2012 Soccer dwight howard Olympics closing ceremony PGA Championship 2012 John Witherspoon george michael
Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/k3VEVBct_tY/
katy perry part of me video photoshop cs6 beta cate blanchett nfl news tebow tebow jets romney etch a sketch
Tennis players, Roger Federer, of Switzerland, and Maria Sharapova of Russia hold a press conference to promote the Gillette Federer Tour, in Sao Paulo, Brazil, Thursday, Dec. 6, 2012. Federer will take on Brazilian Thomaz Bellucci in an exhibition match Thursday evening, Sharapova and Danish tennis star Caroline Wozniacki are scheduled for a Friday match. (AP Photo/Andre Penner)
Tennis players, Roger Federer, of Switzerland, and Maria Sharapova of Russia hold a press conference to promote the Gillette Federer Tour, in Sao Paulo, Brazil, Thursday, Dec. 6, 2012. Federer will take on Brazilian Thomaz Bellucci in an exhibition match Thursday evening, Sharapova and Danish tennis star Caroline Wozniacki are scheduled for a Friday match. (AP Photo/Andre Penner)
Tennis player Roger Federer, of Switzerland, shaves during a press conference to promote the Gillete Federer Tour, in Sao Paulo, Brazil, Thursday, Dec. 6, 2012. Federer will take on Brazilian Thomaz Bellucci in an exhibition match Thursday evening. (AP Photo/Andre Penner)
SAO PAULO (AP) ? Roger Federer says he won't play as often in the next few years but wants to compete in the 2016 Olympics in Rio de Janeiro.
The 31-year-old Swiss star intends to be more mindful about the tournaments he plays to make sure he can keep playing at a high level.
"I have to make sure that I take care of my schedule, of my body, of my mind," he said Thursday. "Hopefully, I can still stay on tour for many more years and hopefully play the Olympics here in three and a half years or so, so I have to look far ahead and not just the next six months."
The winner of 17 Grand Slams is in Sao Paulo for exhibition matches involving Maria Sharapova, Victoria Azarenka, Serena Williams, Caroline Wozniacki, Jo-Wilfried Tsonga, Tommy Robredo, Tommy Haas and Thomaz Bellucci. The Bryan brothers, Bob and Mike, are also participating. Federer plays Bellucci, Brazil's top-ranked player, on Thursday.
Federer has competed in four Olympics, winning a doubles gold in 2008 and a singles silver this year. He would love to make it to the Rio Games.
"There is a lot of passion for sports here," he said. "It's a hot place to play tennis right now."
Federer, who ended the season ranked No. 2, said this year was difficult because of additional commitments that kept him from practice and his family.
"I've played a lot of tennis. It's been a big challenge, especially with the Olympics and the Davis Cup this year," he said. "I found my way back to world No. 1 and it took a lot of sacrifices. I'd like to be home a little bit more often and in a relaxed fashion."
Still, he said it was a rewarding season.
"I'm very happy that I'm still playing at a very high level," said Federer, who won six titles this year, including Wimbledon. "I had one of my best years on tour this year, and one of the most emotional ones, of course. Next year tournament victories will probably be more important than the rankings, that's why I need to make sure I practice a lot next year."
Federer played 19 tournaments in 2012, two more than top-ranked Novak Djokovic. No. 3 Andy Murray also played 19 and Rafael Nadal, nursing a knee injury, played only 11.
"I'm not going to play 25 tournaments, but every tournament that I will be playing I'll be emotionally attached to it because I either won there before or because I've been there many times or because I love the city or the country and the fans," he said. "Today I've reached a point in my life that I can pick and choose where I want to play and how much I want to play."
One of the tournaments he left off his 2013 schedule was Miami, the Masters event in March he has played since 1999 and won twice.
"Miami was a tough decision for me," he said. "But I have to take some time off, first of all, but most importantly, I need to practice. This year I couldn't practice at all. Something had to go in the calendar and that was Miami, unfortunately."
Federer said he thinks he will need two Grand Slams and five to eight titles in other tournaments to get back to No. 1.
"It's difficult," he said. "But I'm happy to set that challenge and I'll give everything I have."
___
Follow Tales Azzoni at http://twitter.com/tazzoni
Associated Pressjk rowling qnexa kingdom of heaven national enquirer whitney houston arizona republican debate arizona debate enquirer
WASHINGTON (AP) ? Sen. John Kerry says Secretary of State Hillary Rodham Clinton has agreed to testify before the Senate Foreign Relations Committee about an independent report on the deadly Sept. 11 attack on the U.S. diplomatic mission in Libya.
In a letter Friday to the panel's members, Kerry indicated that the report from the accountability review board headed by retired diplomat Thomas Pickering is imminent. The Massachusetts Democrat and committee chairman says he's asked that Pickering and retired Adm. Mike Mullen appear before the committee before Clinton. Mullen, the former chairman of the Joint Chiefs of Staff, is a member of the review board.
The attack on the consulate in Benghazi killed U.S. Ambassador Chris Stevens and three other Americans.
Clinton has also agreed to testify before the House Foreign Affairs Committee.
Associated Pressmilwaukee bucks bear grylls us news law school rankings gael glen rice jr bars lindzi cox
