Tuesday, November 27, 2012

Red algae reaches Sydney shores, closes iconic beach

William West / AFP - Getty Images

A swimmer stops short of a red algae bloom at Sydney's Clovelly Beach on Tuesday. Clovelly and Bondi beaches were closed to swimmers.

Sydney's iconic Bondi Beach and Clovelly Beach were closed to swimmers on Tuesday as a red algae bloom drifted close to shore, Agence France-Presse reports.

While the red algae, known as Noctiluca scintillans or sea sparkle, has no toxic effects, people are still advised to avoid swimming in areas with discolored water because the algae, which can be high in ammonia, can cause skin irritation.?

"It has got quite a fishy smell to it,"?lifeguard Bruce Hopkins told?the Australian Associated Press.?"It can irritate some people's skin but generally not much more than that."

William West / AFP - Getty Images

A boy walks along Sydney's Clovelly Beach on Tuesday.

William West / AFP - Getty Images

A seagull stands in a red algae bloom at Sydney's Clovelly Beach on Tuesday.

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Source: http://photoblog.nbcnews.com/_news/2012/11/27/15479564-red-algae-reaches-sydney-shores-closes-iconic-beach?lite

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Monday, November 26, 2012

New molecular culprit linked to breast cancer progression

ScienceDaily (Nov. 23, 2012) ? Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November 5 on the website of the Proceedings of the National Academy of Sciences, details how some tumors get the tools they need to metastasize.

"We've identified a protein that wasn't known before to be involved in breast cancer progression," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine and director of the Vascular Program at Hopkins' Institute for Cell Engineering. "The protein JMJD2C is the key that opens up a whole suite of genes needed for tumors to grow and metastasize, so it represents a potential target for cancer drug development."

Semenza and his colleagues made their finding when they traced the activity of HIF-1, a protein known to switch on hundreds of genes involved in development, red blood cell production, and metabolism in normal cells. Previous studies had shown that HIF-1 could also be hijacked to switch on genes needed to make breast tumors more malignant.

Would-be tumor cells face a host of challenges as they make the transition from working with their host to working against it, such as the need to evade the immune system and to produce more cancer cells, explains Weibo Luo, Ph.D., an instructor in the Institute for Cell Engineering and Department of Biological Chemistry who led the project. All of these efforts require switching on the right genes for the job.

To learn more about how HIF-1 works, the researchers tested a range of human proteins to see whether they would interact with HIF-1. They then sifted through the 200 resulting hits, looking for proteins involved in chemical changes to sections of DNA that determine whether or not the genes they contain are available for use. "In order for HIF-1 to switch genes on, they have to be available, but many of the genes HIF-1 activates are normally locked down in mature cells," explains Luo. "So we thought HIF-1 must have a partner that can do the unlocking."

That partner turned out to be JMJD2C, Luo says. Delving deeper, the researchers found that HIF-1 switches on the JMJD2C gene, stimulating production of the protein. HIF-1's presence also enables JMJD2C to bind to DNA at other HIF-1 target genes, then loosen those DNA sections, enabling more HIF-1 to bind to the same sites and activate the target genes.

To test the implications of their discovery, the research team injected mice with breast cancer cells in which the JMJD2C protein was not produced. Tumors with depleted JMJD2C were much less likely to grow and metastasize to the lungs, confirming the protein's role in breast cancer progression, says Luo.

"Active HIF proteins have been found in many types of tumors, so the implications of this finding go beyond breast cancer," says Luo. "JMJD2C is both an important piece of the puzzle of how tumors metastasize, and a potential target for anti-cancer therapy." Other authors of the research report are Ryan Chang, Jun Zhong, Ph.D., and Akhilesh Pandey, M.D., Ph.D., all of the Johns Hopkins University School of Medicine.

This work was supported by grants from the National Heart, Lung, and Blood Institute (contracts N01-HV28180 and HHS-N268201000032C), and by funds from the Johns Hopkins Institute for Cell Engineering.

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The above story is reprinted from materials provided by Johns Hopkins Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. W. Luo, R. Chang, J. Zhong, A. Pandey, G. L. Semenza. PNAS Plus: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1217394109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/2nYvEp2kt_g/121124090511.htm

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Sunday, November 25, 2012

Boeing using DOMA as excuse to deny benefits to married gay couples (Americablog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

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Car Hire For Safer Travel | travel and leisure article updates

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Source: http://travel-leisure-updates.blogspot.com/2012/11/car-hire-for-safer-travel.html

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'Dallas' star Larry Hagman dies in Texas

In this Thursday, Oct. 9, 2008 photo, actor Larry Hagman listens to a reporter's question while visiting the Southfork Ranch in Parker, Texas, made famous in the television show "Dallas." Actor Larry Hagman, who for more than a decade played villainous patriarch JR Ewing in the TV soap Dallas, has died at the age of 81, his family said Saturday Nov. 24, 2012(AP Photo/Tony Gutierrez)

In this Thursday, Oct. 9, 2008 photo, actor Larry Hagman listens to a reporter's question while visiting the Southfork Ranch in Parker, Texas, made famous in the television show "Dallas." Actor Larry Hagman, who for more than a decade played villainous patriarch JR Ewing in the TV soap Dallas, has died at the age of 81, his family said Saturday Nov. 24, 2012(AP Photo/Tony Gutierrez)

This 1981 file photo provided by CBS shows Larry Hagman in character as J.R. Ewing in the television series "Dallas." Actor Larry Hagman, who for more than a decade played villainous patriarch JR Ewing in the TV soap Dallas, has died at the age of 81, his family said Saturday Nov. 24, 2012. (AP Photo/CBS, file)

FILE - This 1967 file photo shows Barbara Eden, left, and Larry Hagman in a scene from the television show "I Dream of Jeannie." Actor Larry Hagman, who for more than a decade played villainous patriarch JR Ewing in the TV soap Dallas, has died at the age of 81, his family said Saturday Nov. 24, 2012. (AP Photo/NBC, file)

FILE - In this Wednesday, Feb. 19, 2003 file photo, actor Larry Hagman sits in front of a poster of himself during a news conference in Berlin during a tour to promote the German translation of his autobiography. Actor Larry Hagman, who for more than a decade played villainous patriarch JR Ewing in the TV soap Dallas, has died at the age of 81, his family said Saturday Nov. 24, 2012. (AP Photo/Markus Schreiber)

FILE - In this Nov. 4, 2011 file photo, actor Larry Hagman pauses during an interview on location during the filming for the upcoming new television show "Dallas" in Dallas. Actor Larry Hagman, who for more than a decade played villainous patriarch JR Ewing in the TV soap Dallas, has died at the age of 81, his family said Saturday Nov. 24, 2012. (AP Photo/Tony Gutierrez, File)

J.R. Ewing was a business cheat, faithless husband and bottomless well of corruption. Yet with his sparkling grin, Larry Hagman masterfully created the charmingly loathsome oil baron ? and coaxed forth a Texas-size gusher of ratings ? on television's long-running and hugely successful nighttime soap, "Dallas."

Although he first gained fame as nice guy Capt. Tony Nelson on the fluffy 1965-70 NBC comedy "I Dream of Jeannie," Hagman earned his greatest stardom with J.R. The CBS serial drama about the Ewing family and those in their orbit aired from April 1978 to May 1991, and broke viewing records with its "Who shot J.R.?" 1980 cliffhanger that left unclear if Hagman's character was dead.

The actor, who returned as J.R. in a new edition of "Dallas" this year, had a long history of health problems and died Friday due to complications from his battle with cancer, his family said.

"Larry was back in his beloved hometown of Dallas, re-enacting the iconic role he loved the most. Larry's family and closest friends had joined him in Dallas for the Thanksgiving holiday," the family said in a statement that was provided to The Associated Press by Warner Bros., producer of the show.

The 81-year-old actor was surrounded by friends and family before he passed peacefully, "just as he'd wished for," the statement said.

Linda Gray, his on-screen wife and later ex-wife in the original series and the sequel, was among those with Hagman in his final moments in a Dallas hospital, said her publicist, Jeffrey Lane.

"He brought joy to everyone he knew. He was creative, generous, funny, loving and talented, and I will miss him enormously. He was an original and lived life to the fullest," the actress said.

Years before "Dallas," Hagman had gained TV fame on "I Dream of Jeannie," in which he played an astronaut whose life is disrupted when he finds a comely genie, portrayed by Barbara Eden, and takes her home to live with him.

Eden recalled late Friday shooting the series' pilot "in the frigid cold" on a Malibu beach.

"From that day, for five more years, Larry was the center of so many fun, wild and sometimes crazy times. And in retrospect, memorable moments that will remain in my heart forever," Eden said.

Hagman also starred in two short-lived sitcoms, "The Good Life" (NBC, 1971-72) and "Here We Go Again" (ABC, 1973). His film work included well-regarded performances in "The Group," ''Harry and Tonto" and "Primary Colors."

But it was Hagman's masterful portrayal of J.R. that brought him the most fame. And the "Who shot J.R.?" story twist fueled international speculation and millions of dollars in betting-parlor wagers. It also helped give the series a place in ratings history.

When the answer was revealed in a November 1980 episode, an average 41 million U.S. viewers tuned in to make "Dallas" one of the most-watched entertainment shows of all time, trailing only the "MASH" finale in 1983 with 50 million viewers.

It was J.R.'s sister-in-law, Kristin (Mary Crosby) who plugged him ? he had made her pregnant, then threatened to frame her as a prostitute unless she left town ? but others had equal motivation.

Hagman played Ewing as a bottomless well of corruption with a charming grin: a business cheat and a faithless husband who tried to get his alcoholic wife, Sue Ellen (Gray), institutionalized.

"I know what I want on J.R.'s tombstone," Hagman said in 1988. "It should say: 'Here lies upright citizen J.R. Ewing. This is the only deal he ever lost.'"

On Friday night, Victoria Principal, who co-starred in the original series, recalled Hagman as "bigger than life, on-screen and off. He is unforgettable, and irreplaceable, to millions of fans around the world, and in the hearts of each of us, who was lucky enough to know and love him."

Ten episodes of the new edition of "Dallas" aired this past summer and proved a hit for TNT. Filming was in progress on the sixth episode of season two, which is set to begin airing Jan. 28, the network said.

There was no immediate comment from Warner or TNT on how the series would deal with Hagman's loss.

In 2006, he did a guest shot on FX's drama series "Nip/Tuck," playing a macho business mogul. He also got new exposure in recent years with the DVD releases of "I Dream of Jeannie" and "Dallas."

The Fort Worth, Texas, native was the son of singer-actress Mary Martin, who starred in such classics as "South Pacific" and "Peter Pan." Martin was still in her teens when he was born in 1931 during her marriage to attorney Ben Hagman.

As a youngster, Hagman gained a reputation for mischief-making as he was bumped from one private school to another. He made a stab at New York theater in the early 1950s, then served in the Air Force from 1952-56 in England.

While there, he met and married young Swedish designer Maj Axelsson. The couple had two children, Preston and Heidi, and were longtime residents of the Malibu beach colony that is home to many celebrities.

Hagman returned to acting and found work in the theater and in such TV series as "The U.S. Steel Hour," ''The Defenders" and "Sea Hunt." His first continuing role was as lawyer Ed Gibson on the daytime serial "The Edge of Night" (1961-63).

He called his 2001 memoir "Hello Darlin': Tall (and Absolutely True) Tales about My Life."

"I didn't put anything in that I thought was going to hurt someone or compromise them in any way," he told The Associated Press at the time.

Hagman was diagnosed in 1992 with cirrhosis of the liver and acknowledged that he had drank heavily for years. In 1995, a malignant tumor was discovered on his liver and he underwent a transplant.

After his transplant, he became an advocate for organ donation and volunteered at a hospital to help frightened patients.

"I counsel, encourage, meet them when they come in for their operations, and after," he said in 1996. "I try to offer some solace, like 'Don't be afraid, it will be a little uncomfortable for a brief time, but you'll be OK.' "

He also was an anti-smoking activist who took part in "Great American Smoke-Out" campaigns.

Funeral plans were not immediately announced.

"I can honestly say that we've lost not just a great actor, not just a television icon, but an element of pure Americana," Eden said in her statement Friday night. "Goodbye, Larry. There was no one like you before and there will never be anyone like you again."

___

Associated Press writers Erin Gartner in Chicago and Shaya Mohajer in Los Angeles, and AP Television Writer Frazier Moore in New York contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-11-24-Obit-Hagman/id-f3b8c8e70efe4f2f94cbc4abf13ca654

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Video: Review: The debates that never ended

Don't be fooled! Great camera deals are harder to spot on Black Friday

While there are plenty of deals and discounts to be had on TVs, phones, laptops and other tech products, camera-wise, there aren't a lot of reasons to wait in line until midnight after Thanksgiving dinner. That's because the year's best cameras ? many of which are rounded up here ? simply aren't subject to fire-sale pricing.

Source: http://www.msnbc.msn.com/id/3036697/vp/49903755#49903755

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